To accomplish useful tasks in computation, communication, or sensing, qubits have to be integrated into larger systems. Pioneering theoretical work in the areas of quantum computer architecture and fault-tolerant error correction has provided estimates of the resources and key components required to build large-scale quantum computers. Experimental work on scaling up qubit platforms has led to the identification of new challenges, such as controlling cross-talk in large qubit arrays, developing efficient classical control interfaces, and realizing modular quantum communication channels between remote qubits. Research at Princeton on quantum systems architecture explores a new frontier of applying systems engineering and computer architecture concepts to quantum systems. The interplay between systems engineering and qubit design will allow for more efficient utilization of existing qubits, and focus efforts for new qubit development.